Specific guide to this web site for:
2. Medical Students
3. Science media writers
4. High School & College
1. Harvard led MI study
(J. of Amer. Coll.
4. Amer. J. of Cardio.
review of literature
6. Oat bran study
7. Pregnancy & Alcohol
8. Are Geminis
9. Columbia 'Miracle' Study
Limitations of Meta-Analyses
Large Randomized Clinical
Tale of Two Large
of Meta-Analyses (details)
A meta-analysis is subject to potential problems and pitfalls just as a clinical
trial is subject to potential limitations. Despite the perception by some
that a meta-analysis is always the final word on a topic, a meta-analysis can
result in incorrect or incomplete conclusions.
Very Large Randomized Clinical Trial: Strengths and Weaknesses (details)
A very large randomized clinical trial is the gold standard for assessing the
benefits of a medical treatment. Though large randomized trials have many
strengths, this is not an inherent guarantee that a trial is constructed well or
reaches appropriate conclusions.
A Tale of Two Large Trials (details)
The Heart Protection Study (HPS) is a superbly designed and interpreted large
randomized clinical trial in contrast to the ALLHAT trial which is a large
randomized trial which reached conclusions not proven by the trial data.
Beware of Meta-analyses Bearing False Gifts (details)
Meta-analyses performed by strong advocates of a particular position in an
ongoing controversy are particularly at risk for bias.
meta-analyses (details) Network
meta-analyses are more prone to unreliable conclusions.