Specific guide to this web site for:
Large Randomized Clinical Trials
The Self-Correcting Nature of Science
One of the major reasons why medical treatment and medical knowledge have successfully advanced is that the information is based on the scientific method. The scientific method relies upon reproducible experimental results and studies. Theories of what constitute the best treatment can be verified or found to be false by subsequent well done and well interpreted clinical trials. Clinical randomized trials, as well as basic science experiments can build upon prior experimental findings. The field of medicine can progress over time far more easily than descriptive fields such as sociology or economics where the experimental verification of theories is much more difficult to conduct.
“10 Years – Later”
To show the self correcting nature of medical research over time, an examination of what
h as subsequently occurred or is
speculated to occur in the future for each of the statistical problems reviewed in this
web site is as follows:
as subsequently occurred or is speculated to occur in the future for each of the statistical problems reviewed in this web site is as follows:
Extremely poor statistical analysis in an article in the Journal of the
American College of Cardiology.
Very poor article in the New England Journal of Medicine. "10 years
Incorrect review of literature regarding dosage of aspirin required
patients presenting with a threatened heart attack. "10 years later"
influential trial (ALLHAT) that made recommendations far beyond what its data warranted in
regards to the initial treatment of hypertension.
Underpowered widely publicized study poorly done study suggesting oat
bran had no significant cholesterol lowering
properties. "10 years later"
Pregnancy and low levels of alcohol ingestion. "10 years later"
Inappropriate and unreliable subgroup analyses being performed. "10 years later"
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